The so called Angel Of Death child killer is believed to be battling for her life with suspected sepsis.
Beverley Allitt , now 49, was convicted of killing four children while working as a nurse at Grantham and Kesteven Hospital, Lincs, in 1991.
She is being held at Rampton high-security hospital and is said to be receiving 24 hour care after falling ill on Sunday.
A source told The Sun: There are genuine concerns as to whether shell pull through.
Allitt took her first victim, eight-week old Liam Taylor, in February 23, 1991 after she injected the child with a fatal amount of insulin.
The ex-paediatric nurse went on to kill three more and critically injured nine others during the 59-day killing rampage at the hospitals Ward 4.
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The sudden rise in infant mortalities confused hospital management and created a frantic investigation into their deaths.
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Some children were left with life-long injuries resulting from the harmful injections.
She went on trial at Nottingham Crown Court in 1993, pleading not guilty.
The jury heard that psychiatrists who had examined her had decided she was suffering from Munchausen Syndrome by proxy, a mental illness where sufferers yearn for attention.
She was found guilty and ordered to be held indefinitely in Rampton High Security Psychiatric Hospital.
Sepsis, also known as septicemia, is a deadly disease that causes the bodys immune system to attack its own tissue and organs as it attempts to fight infection.
More: UK
Symptoms may include fever, urinary problem and low blood pressure and may lead to death if antibiotic treatment fails.
Nottinghamshire Healthcare NHS has declined to comment on Allitts condition.
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